Forest managers in the United States must respond to the need for climate-adaptive strategies in the face of observed and projected climatic changes. However, there is a lack of on-the-ground forest adaptation research to indicate what adaptation measures or tactics might be effective in preparing forest ecosystems to deal with climate change. Natural resource managers in many areas are also challenged by scant locally or regionally relevant information on climate projections and potential impacts. The Adaptive Silviculture for Climate Change (ASCC) project was designed to respond to these barriers to operationalizing climate adaptation strategies by providing a multiregion network of replicated operational-scale research sites testing ecosystem-specific climate change adaptation treatments across a gradient of adaptive approaches, and introducing conceptual tools and processes to integrate climate change considerations into management and silvicultural decisionmaking. Here we present the framework of the ASCC project, highlight the implementation process at two of the study sites, and discuss the contributions of this collaborative science-management partnership.